Nowadays people have discovered so many problems. But actual problem - janma-mrtyu-jara-vyadhi - they are not very much serious. Therefore they have been described here as pramattah, madmen. He does not know what is the real problem, but he is very busy with the superficial problems. Therefore sastra says that these people, blind, they do not know what is the problem.
Lecture on Srimad-Bhagavatam 2.1.4, Vrndavana, March 19, 1974